Bessie Head--Thunder Behind Her Ears, Her Life and Writing

Ali Kosh Lady and her Artificially Modified Head: An Appraisal

We had the opportunity to examine the cranium of a young woman found at the well-known Neolithic site of Ali Koshon the Deh Luran plain in southwestern Iran. It has previously been claimed that her head shows traces of modification,a practice which can be termed as either cultural or artificial cranial modification. Here, we describe several macroscopiccharacteristics of the modified crania and...

Music to Her Ears? Male Mice Sing an Ultrasonic Tune

Background: The expression level of osteopontin correlates with the metastatic potential of several tumors. Osteopontin is a well-characterized ligand for the αvβ3 integrin. The present study was undertaken to elucidate the possible role of osteopontin/αvβ3 signaling in prostate cancer cell migration. Results: We generated stable prostate cancer cell (PC3) lines that over-express osteopontin (P...

Mary Wollstonecraft, Her Tragic Life and Her Passionate Struggle for Freedom

Soluble HER-2 in Patients with Head and Neck Squamous Cell Carcinoma

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...

Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.

A significant number of HER-2 amplified breast cancers is effectively treated by trastuzumab and further shows receptor-enhanced chemosensitivity. Recent studies have postulated transactivation of HER-2 also in tumors expressing phosphorylated/activated HER-2 (pHER-2) and of the HER-3/HER-4 ligand heregulin (HRG), independent of HER-2 amplification. As a consequence, a subset of tumors without ...